Cost-effectiveness analysis of abiraterone, docetaxel or placebo plus androgen deprivation therapy for hormone-sensitive advanced prostate cancer

Cost-effectiveness analysis of abiraterone, docetaxel or placebo plus androgen deprivation therapy for hormone-sensitive advanced prostate cancer

Blog Article

ABSTRACT 3m speedglas 9002nc Objective To evaluate the cost-effectiveness of the addition of chemotherapy or abiraterone to androgen deprivation.Methods We developed an analytical model to determine the cost-effectiveness of the addition of docetaxel or abiraterone versus androgen deprivation therapy alone.Direct and indirect costs were included in the model.The effects were expressed in Quality-Adjusted Life Years adjusted for side effects.

Results Compared to androgen deprivation therapy alone, the addition of chemotherapy and of abiraterone generated 0.492 and 0.999, respectively, in Quality-Adjusted Life Years.Abiraterone led to a Quality-Adjusted cent dyyni Life Years gain of 0.

506 compared to docetaxel.The incremental costs per Quality-Adjusted Life Years were R$ 133.649,22 for docetaxel, R$ 330.828,70 for abiraterone and R$ 571.

379,42 for abiraterone compared to docetaxel, respectively.Conclusion The addition of chemotherapy to androgen deprivation therapy is more cost-effective than the addition of abiraterone to androgen deprivation therapy.However, discounts on abiraterone cost might improve cost-effectiveness.